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许小娟

许小娟,博士,教授武汉大学化学与分子科学学院教授,

  • 中文名称 许小娟
  • 国籍 中国
  • 毕业院校 武汉大学
  • 学位/学历 博士
  • 职业 教师

人物经历

  教育与研究经历

  199字到班续核3.9-1997.6,理学学士,武汉大学化学学院

  1997.9-2002.6,理学博士,武汉大学化学与分子科学学院

  2000.4-2001.3,特别研究生,日本大阪大学理学部高分子科的同不划错的点预学系(从事多糖溶液来自性质研究)

  2001.7-,助教、讲师、副教授、教授/博导,武汉大学化学与分子科学学院

  2008.11-2010.10,日本学术振兴会(JSPS)外国人特别研究员,日本神户大学(从事多糖生物学研究)

  教学情况

  本科生课程:《高分子导论》、《高分子合成与表征》

  研究生课程:《高分子360百科物理近代研究方法》、《高分子科学进展》

研究领域

  一、多糖溶液

  1、多糖链构象及表征方法

  2、多糖溶液行为(聚集、溶液-凝胶转变、自组装、流变鲜执诗穿自万天意误溶善行为等)

  3、多糖纳米复合物的构建、功能及构效关系

  林查久背二、多糖生物学

  1、多糖与DNA/RNA的相互作

  2、多糖及其衍生物的生物活性及构效关系

  3、多糖及其衍生物诱导的细攻后表胞内信号转导

科研项目

  1、教育部新世纪优秀人才支持计划(NCET-13来自-0442),2014-2016。(主持)

  2、国家自然科学重点基金360百科(21334005),2014.1-2017.1换移质营意干燃超钱简2。(参加)

  3、武汉市"黄鹤英才计划",2013.1-2016.12。(主持)

  4、国家自然科学基金(21274114),2013.1-2016.12。(主持)

  5、国家水移令效自然科学基金(20874078),2009.1~2011.12。(主持)

  6、武汉市青年科技晨光计划(200950431193), 200权星重英副9.1-2011.12。(主持)

  7、国家自然科学基金(20处展体本凯见脱带运出404010),2005.形台脸复剧物程酸1-2007.12。(主持)

  8、湖北省自然科学基金, 2005.1-2006.12。(主持)

发表论文

  1. Liu Q., Cao Y., Xu H., Li M., Xu X., Zhang L., Transfection efficiency and internalization of the gene 史消放剂息棉架沙危演carrier pr四言评帝权边来epared from a 使异东态triple he素继lical b-glucan and polydeoxyadenylic acid in macrop害格探井比破hage RAW264.7 cells, J. Mater. Chem. B, 2015, 3, 3789-3798.

  2. Fang Y., Duan B., Lu A., Liu M., Liu H.钢属液入福, Xu X., Zhang L., Intermolecular interaction and the extended wormlike chain conf拿素入号时须又宜设ormation of chitin in NaOU/urea aqueous solution, Biomacromolecules, 2015,16,1410-14磁出17.

  3. Liu Q., Wang C., Cao Y., Xu X.*, Zh权买浓感ang L., A novel gene delivery system prepared from beta-glucan and polydeoxyadenylic acid via disulfide bonds. J. Mater. Chem. B, 2014, 2, 933-944. (cover paper)

  4. Jia X., Xu X.*, Zhang L. Synthe兰族次待宁东报通sis and Stabilization of Gold Nanoparticles Induced by Den定如美花法aturation an么福够易比药发三各作八d Renaturation of Triple Helical b-Glucan in Water. Biomacromolecules, 2013,14, 1787-1794.

  5. Xu S., Lin Y., Huang J., Li Z., Xu X.*, Zhang L.*, Construction of high strength hollow fibers by self-assembly of a stiff polysaccharide with short branches in water. J. Mater., Chem. A, 2013, 1, 4198-4206.

  6. Liu Q., Xu X.*, Zhang L., Luo X., Liang Y., Assembly of single-stranded polydeoxyadenylic acid and b-Glucan probed by the sensing platform of graphene oxide based on the fluorescence resonance energy transfer andfluorescence anisotropy. Analyst, 2013, 138, 2661-2668.

  7. Xu X.*, Yasuda M., Mizuno M., Ashida H.* β-Glucan from Saccharomyces cerevisiae reduces lipopolysaccharide-induced inflammatory responsesin RAW264.7 macrophages. Biochim. Biophys. Acta, 2012, 1820, 1656-1663.

  8. Xu X.*, Yasuda M., Nakamura-Tsuruta S., Mizuno M., Ashida H.*, b-glucan from Lentinus edodes inhibits nitric oxide and tumor necrosis factor-a and phosphorylation of mitogen-activated protein kinases in lipopolysaccharide stimulated murine RAW 264.7 macrophages. J. Biol. Chem., 2012, 287, 871-878.

  9. Xu X.*, Chen P., Zhang L., Ashida H., Immunomodulatory b-glucan from Lentinus edodes activates mitogen-activated protein kinases and nuclearfactor-kB in murine RAW 264.7 macrophages. J. Biol. Chem., 2011, 286, 31194-31198.

  10.Xu S., Xu X.*, Zhang L.* Branching structure and chain conformation of water-soluble glucan extracted from Auricularia Auricula-Judae. J. Agric. Food Chem.2012, 60, 3498-3506.

  11. Li S., Zhang Y., Xu X., Zhang L., Triple helical polysaccharide-induced good dispersion of silver nanoparticles in water. Biomacromolecules, 2011, 12, 2864-2871

  12.Zhang Y, Xu X.*, Zhang L., Dynamic viscoelastic behavior of triple helical Lentinan in water. Effects of concentration and molecular weight.Polymer, 2007, 48, 6681-6690.

  13.Xu X., Zhang X., Zhang L., Wu C., Collapse and association of denatured lentinan in water / dimethylsulfoxide solution, Biomacromolecules, 2004,5, 1893-189

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